Henderson learned the trumpet at school and studied music at the San Francisco Conservatory of Music (1954-57). There followed three years in the Air Force. He was already playing enough music to be encouraged by Miles Davis to develop his jazz. He returned to academic study, graduating in zoology (1964) and then in medicine (1968) and since 1975 has continued to work as a general practitioner and psychiatrist alongside his musical career. During summer holidays he played with John Handy and then with Handy and Philly Joe Jones when he graduated. He played with Herbie Hancock’s sextet (1970-73) before spending six months with Art Blakey’s Jazz Messengers. Since then he has led his own jazz rock groups and even achieved chart success with a track from Comin’ Through (1977). At the end of the 90s he was recording with Joe Locke, Kevin Hays, Billy Drummond and Ed Howard.